Genome Guardian update 4.2.2 is now rolling out on PC (Steam). According to the official Genome Guardian patch notes, the latest update 4.2.2 added quality of life improvements and gameplay optimizations.
Since the last patch, players are facing a number of problems with the game. Today’s Genome Guardian patch 4.2.2 will fix a few of these issues.
Check out more details below.
Genome Guardian Patch 4.2.2 Notes – July 24, 2024
BALANCE
- It’s now slightly more likely for a weapon mod to be white (compatible with any weapon).
- (turret) Hotdog: I want it to feel more distinct from Daisy, thus:
- Now has 2 weapon mounts (each holds 2 DNA Letters and 4 weapon mods).
- No longer has -20% Firerate.
- (turret) Surge: Recharge Rate 3/s → 3.75/s (which, where the stat is displayed, will show as 4/s).
CHANGES
- The “DNA Letter On Items” setting will no longer append the DNA Letter to the name of weapons in the shop (their letter is literally their icon so it’s impossible to miss :P).
- (turret) Jester: an additional means of unlocking this turret has been added.
FIXES
- A recent update caused the message that appears near the top of the screen during a wave to sometimes not show (for instance, “wave ending!” stopped appearing).
- Speaking of which, text will inform you that a mutation is imminent when one will occur after the current wave (this is hidden until you’ve gotten past wave 15 on your save).
- Turret stats for your selected turret would be incorrect (they’d be what you’d have if you had no Intro Research) when viewing its stats in the TURRET menu.
Download Genome Guardian update 4.2.2 on PC.

